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Pranav Kodali

Current Undergraduate Student

Undergraduate
Pranav.kodali [ at ] vanderbilt.edu
Vanderbilt University - MBRIII 5140 Office Suite

Research Interests:

  • Antibodies
  • Rosetta
  • Antibody design
  • Vaccine
  • Homology modeling


The Vanderbilt Program for Next Generation Vaccines aims to integrate big data and structural biology into the design pipeline for new vaccines. One crucial step in this process is the modeling of the 3D structures of antibodies from their amino acid sequences. Comparative modeling of antibodies is usually applied using only one structure as a template for the entire antibody (single template modelling) or one structure as a template for each CDR and the entire framework regions (RosettaAntibody modelling). However, the use of multiple templates (multi-template modelling) has been shown to improve the accuracy of modeling for other types of proteins. I am working on a protocol that utilizes multitemplate modeling in RosettaCM to improve the modeling of antibodies.

 

 

Publication Link:


https://scholar.google.com/citations?hl=en&user=62K2DsMAAAAJ
 

 

Supervised by: Clara T. Schoeder


  • Research Projects
  • Publications