Computational Chemical and Structural Biology
Current Post-Doctoral Fellow
B.S. ACS Chemistry, B.A. Biology, Northwest Missouri State University
jordan.r.willis [ at ] vanderbilt.edu
1. High resolution binding energies associated with antibody neutralization of HIV. Using this binding energy to correlate neutralization of HIV we can design systematic mutations to engineer an antibody to regain neutralization of an antibody to a highly mutated HIV variant that has escaped neutralization.
2. Low Resolution homology modeling of neutralizing antibodies that we find in infectious blood. We can then use Rosetta Dock to find binding epitopes to rule out which of these epitopes are important in eliciting neutralizing antibody production.
3. Entropy/Enthalpy energy scoring to find out the importance of distal mutations that occur during affinity maturation that are not at the antigen binding interface.