Group Members

portrait

Yan Xia

Current Graduate Student

B.S. NTU
yan.xia [ at ] vanderbilt.edu
5154E

Research Interests:

Characterising the TSPO structure and ligand binding mechanism. 
The translocator protein is an important outer mitochondrial membrane protein that facilitate cholesterol transport, oxidative stress sensing and apoptosis. We uses Nuclear Magnetic Resonance (NMR) spectroscopy, Electron Paramagnetic Resonance (EPR) spectroscopy and computational modelling to characterise the structure and ligand binding induced conformational changes of the protein. 
Computational modelling to shed light on metabotropic glutamate receptors (mGluRs) signalling. 
We employ a variety of computational ligand docking and protein-protein docking method in Rosetta to formulate hypothesis on how inter-domain signal transduction, receptor activation/inactivation in mGluRs based on published structure.