Jens Meiler and Jarrod Smith receive S10 instrumentation grant!
Jens Meiler and Jarrod Smith receive S10 instrumentation grant from NIH to bolster High-Performance Computing for Biomedical Research at Vanderbilt University!
Congratulations, Jens and Jarrod!
Srihari Chandra receives the VUSRP ACCRE Scholar Fellowship!
Srihari Chandra receives the Vanderbilt Undergraduate Summer Research Program (VUSRP) ACCRE Scholar Fellowship for his research on Protein Folding.
Way to go Srihari!
receives prestigious NSF Graduate Research Fellowship!
Brennica Marlowreceives prestigious NSF Graduate Research Fellowship for her research onCholesterol Membrane Protein Interactions.
Way to go Brennica!
Jens Meiler was elected member of the Saxon Academy of Sciences in Leipzig
Former Meiler lab student Brittany Allison accepted a position as program coordinator of the SYNERGI program
Former Meiler lab student Brittany Allison accepted a position as program coordinator of the SYNERGI program, which supports underrepresented freshmen and sophomores who are interested in science research.
Lisa Pankewitz from the University of Leipzig receives a PROMOS scholarship!
Lisa Pankewitz from the University of Leipzig receives a PROMOS scholarship to pursue her Master’s thesis research in the Meiler laboratory on membrane protein structure determination.
Introducing Vanderbilt’s Program for Next Generation Vaccines – Integrating Structural Biology with Big Data
Please see the link below for the full article.
Axel Fischer passed his Qualifying Exam!
Axel Fischer passed his Qualifying Exam defending his proposal "In silico prediction of protein structures and ensembles".
REU is funded!
NSF recommends the Rosetta Research Experience for Undergraduates (REU) program for funding! Apply now at https://www.rosettacommons.org/about/intern
New protein crystal structure
The crystal structure of TIM-barrel protein HisF-C9S
has been released.
VICC trial putting lung cancer therapy to the test
VUMC News Article
Study reveals new clues to cystic fibrosis 'gender gap'
VUMC News Article
Former Meiler lab student Stephanie DeLuca accepted a position in Senator Elizabeth Warren’s office
Stephanie DeLuca accepted a position as BPS/AAAS Congressional Science and Engineering Fellow in Senator Elizabeth Warren's office.
Congratulations to Jonathan Sheehan for 3rd poster prize!
Congratulations to Jonathan Sheehan and his team for 3rd poster prize atPersonalized Medicine Day for his presentation "Program in PersonalizedStructural Biology at Vanderbilt University"
Study reveals new clues to cystic fibrosis ‘gender gap’
Thank you for your contribution, Jens!
Meiler and Crowe labs receive $390,000 to study Ebola virus!
Congratulations! See story here:
Young Scientist in the news! Way to go, Jens!
Interdisciplinary group of Vanderbilt researchers lead by Drs. Meiler and Crowe receive TIPs funding!
The trans-institutional program (TIPs) funding will be to develop Next Generation Vaccines Integrating Structural Biology with Big Data. Congratulations!
Greg Sliwoski receives NLM Biomedical Informatics Postdoctoral Fellowship
Greg will be a postdoctoral fellow in Dr. Tony Capra's lab. Congratulations, Greg!
Nina Bozhanova returns from Moscow for 2 months to continue work on Fluorescence-activated proteins in Rosetta
Welcome back, Nina!
Drs. Sam DeLuca, Stephanie DeLuca, Sten Heinze, Daniel Putnam, Brittany Allison hooded in Graduation Ceremony!
Congratulations to our recent Meiler Lab graduates! The ceremony took place on May 13th
Jens promoted to full Professor of Chemistry, Pharmacology, and Biomedical
Nick Steyns arrives from University of Bonn for 6 months to investigate selective inhibitors for DDR1
Alex Geanes, a graduate student in Chemistry, passed his qualifying exam!
Henrike Indrischek arrives from Leipzig University to work on binding of visual arrestins for 3 months
Meiler Lab Team wins 3rd Place at Shade Tree Trot 5K!
Congratulations to The Extra Meilers!
Bian Li, a graduate student in Chemistry, passed his qualifying exam!
Daniel Putnam successfully defended his PhD thesis!
Daniel's thesis was entitled: BCL::SAS-Small Angle X-Ray/Neutron Scattering Profiles to Assist Protein Structure Prediction. Congratulations, Dr. Putnam!
Brittany Allison successfully defended her PhD thesis!
Brittany successfully defended her dissertation entitled "Computational Design of Protein-Ligand Interfaces Using RosettaLigand" Congratulations, Dr. Allison!
Graduate Student Alex Sevy will give an oral presentation at Antibody Biology and Engineering GRC
His talk will be on "Generating broadly neutralizing antibodies via computational design"
Postdoc Amandeep Sangha will give oral presentation at Antibody Biology and Engineering GRC
Her talk will be on "Discovery and design of human antibodies to broadly neutralize flioviruses"
Georg Kuenze, postdoctoral fellow, receives a scholarship from the German Science Foundation (DFG)
Congratulations, Georg! Georg's project is on membrane protein structure determination from limited NMR data
Bian Li receives predoctoral fellowship from the American Heart Association!
His proposed project is "Predicting Deleterious Mutations in the Potassium Channel KCNQ1 that Can Cause Long QT Syndrome" Congratulations, Bian!
Greg Sliwoski successfully defends his PhD thesis!
Congratulations, Dr. Sliwoski!
Rosetta Workshop 11-13-15 concludes with Protein-Ligand Docking and Structure Refinement tutorials
Rosetta Workshop is hosted by the Meiler Lab
Rosetta Workshop 11-12-15 Protein-Protein Docking and Protein Design tutorials!
Rosetta Workshop is hosted by the Meiler Lab
Rosetta Workshop begins! Tutorials today are de novo folding and Comparative Modeling!
Rosetta workshop is hosted by the Meiler Lab.
Brian Bender passed phase II of his qualifying exam!
Amandeep Sangha gives oral presentation at SERMACS/SWRM meeting!
Amandeep has been chosen to present her work on "Designing neutralizing antibodies for Marburg and Ebola viruses" at the joint American Chemical Society Southeastern Regional Meeting (SERMACS) and Southwest Region Meeting (SWRM) in Memphis Nov 4-7th, 2015.
Ben Mueller receives fellowship from NIH Training Program!
The training program is for Ion Channel and Transporter Biology at Vanderbilt University. Congratulations, Ben!
Axel Fischer successfully passes his preliminary exam!
Heather Darling elected Valedictorian Plant Ops University!
Jens Meiler receives the prestigious Friedrich Wilhelm Bessel-Prize of the
Alexander von Humboldt Foundation
Alex Sevy passed his Qualifying Exam!
Alex is in the Chemical and Physical Biology program. Congratulations, Sevy!
Brittany Allison was selected for an oral presentation and travel grant for NOBCChe conference
Brittany will travel to the Orlando conference to present her research. Congratulations on receiveing the NOBCChe Advancing science travel grant, Brittany!
Daniel Putnam awarded prestigious Oak Ridge National Laboratories Fellowship!
Daniel received the fellowship through the Office of Science Graduate Student Research at ORNL. These awards are given to outstanding US graduate students to complement their graduate research. He will spend 4.5 months at ORNL working on structure determination of cellulose synthase transmembrane domain in Arabidopsis Thaliana using neutron scattering and high performance computing beginning in October. Congratulations, Daniel!
Daniel Putnam's SAXS review was endorsed by BIOISIS
Daniel's review as endorsed as an "Excellent review on SAXS, this should be required reading material for anyone wanting to learn SAXS." BIOISIS is an open access database dedicated to the study of biological macromolecules by small angle X-ray scattering (SAXS) and aims to become the complete source for the deposition, distribution and maintenance of small angle X-ray scattering data and technologies
Don Davis awarded Warren Fellowship!
Chemistry summer student Don Davis was awarded a Warren Fellowship for this summer. Congratulations, Don!
Michaela Fooksa receives Molecular Biophysics Training Grant!
The grant typically supports students for 2 years. Congraulations, Michaela!
Cristina Martina receives travel award for Protein Society Conference-Barcelona!
Cristina was a visiting student in the Meiler lab. Congratulations, Crisitina!
Meiler Lab Alumni to participate in commencement ceremonies this Friday, May 8th
Congratulations to Mariusz, Liz, Sten, and Elizabeth!
Sam DeLuca successfully defends his PhD thesis
Sam successfully defended his dissertation entitled "Development of Novel Methods for Computational Protein Design and Protein-Ligand Docking." Congratulations, Dr. DeLuca!
Alyssa Lokits receives a travel award for the Protein Society Conference-Barcelona!
Jeff Mendenhall and Bian Li receive second place at Personalized Medicine Day poster session!
Jeff and Bian presented on "Prediction of KCNQ1 Mutations Associated with Long-QT Syndrome." Congratulations!!
Elizabeth King receives highest honors for her honors thesis!
Elizabeth's undergraduate honors thesis was entitled " Structural Studies on Growth Hormone Secretagogue 1a and Ghrelin Interactions." Congratulations, Elizabeth!
Jonas Meiler won the Shade Tree Trot 5K!
Jonas was competing in the 0-9 age group. Congratulations, Jonas!!
Alex Sevy receives honorable mention for the NSF Graduate Research Fellowship!
Kelli Kazmier accepts lecturer position at Rollins College
Meiler laboratory graduate accepted a 2-year lecturer position at Rollins College in Orlando, Florida. Congratulations, Kelli!
Alex Geanes receives NSF Graduate Research Fellowship!
The fellowship includes a 3-year stipend. Congratulations, Alex!
Steffen Lindert accepts assistant professorship at The Ohio State University
Meiler laboratory graduate accepted an assistant professorship position in the Chemistry Department at The Ohio State University in Columbus, Ohio. Congratulations, Steffen!
Brittany Allison was featured on NSF's tumblr page for Women's History Month!
Great job, Brittany! See the post here: http://nationalsciencefoundation.tumblr.com/post/112625916214/inspired-by-role-models
John Lally receives a Vanderbilt University Summer Research Program Fellowship!
Daniel Putnam defended his PhD research proposal successfully!
Darwin Fu passed his Qualifying Exam!
Rosetta Workshop at the 2015 Keystone "Hybrid Methods in Structural Biology"
Rocco Moretti presented workshop materials to 60 participants!
Jens Meiler organized the 2015 Keystone Meeting "Hybrid Methods in Structural Biology"
The meeting took place on March 4-8 at Lake Tahoe and had 160 participants
Congratulations, Dr. Heinze!
Sten Heinze successfully defended his dissertation entitled "Improvements for BCL::Fold de novo protein structure prediction".
Dr. Jens Meiler named Chancellor Faculty Fellow!
Dr. Meiler was one of fifteen faculty members selected for the Chancellor Faculty Fellows Program. This competitive program recognizes and supports outstanding young scholars from a diverse set of disciplines across Vanderbilt's campus. (http://www.vanderbilt.edu/provost/initiatives/chancellors-fellows-program/
) Congratulations, Jens!
Alyssa Lokits passed her Qualifying Exam!
Alyssa passed phase II of her qualifying exam in the Neuroscience department. Congratulations!
Bian Li passed his preliminary exam
Alex Geanes wins Division of Chemical Information (CINF) Scholarship for Scientific Excellence!
Alex received this award for his poster presentation at the ACS meeting in San Francisco. Congratulations, Alex!
Congratulations, Dr. DeLuca!
Stephanie Hirst DeLuca successfully defended her dissertation entitled "Protein Structure Elucidation by Combining Computational and Experimental Methods"
Alyssa Lokits passed Phase I of her qualifying exam!
Protein Tweets: A conserved phenylalanine as relay between subunits of G-protein coupled receptors
A conserved phenylalanine is found to be a critical relay between the alpha5 helix and the GDP binding region of heterotrimeric Gi protein alpha subunit. Published in JBC! Read all about it here: http://www.jbc.org/content/early/2014/07/18/jbc.M114.572875
Darwin Fu wins a Phrma Fellowship
Darwin Fu won an informatics graduate student fellowship from the Phrma foundation. Congratulations, Darwin!
Meiler Lab awarded Vanderbilt University Central Discovery Grant!
The Meiler Laboratory is one of several laboratories that have been awarded a University Central Discovery Grant for the proposal entitled "An Intel Xeon Phi Coprocessor (IXP-CPU) Computing Cluster for ACCRE". Congratulations!
Alex Geanes receives CBI training grant!
New ROSIE Ligand Docking App
The Ligand Docking ROSIE app is now available! Please visit: http://rosie.rosettacommons.org/ligand_docking
Congratulations, Dr. Butkiewicz!
Mariusz Butkiewicz successfully defended his dissertation entitled: Advancing Quantitative Structure Activity Relationship Strategies in ligand-based Computer-Aided Drug Design.
Congratulations, Dr. Willis!
Jordan Willis successfully defended his dissertation entitled: Rational Antibody Design: From Mechanisms of Binding to Novel Vaccine Strategies.
Amanda Duran passed her qualifying exam!
Linking the alpha-5 helix to GDP release article receives a F1000 recommendation!
The Most Detailed Picture Ever of Protein Linked to Learning, Memory, Anxiety, Pain and Brain Disorders
Yan constructed a full length model of Metabotropic Glutamate Receptor 1 and docked a focused library of ligands according to their Structure-Activity Relation.
Sign up now for the 2014 Rosetta Workshop
Whether you are a Rosetta newcomer or an advanced user, you are invited to take part in our 2014 Rosetta workshop, April 28 - May 1, to learn how Rosetta can be used for protein modeling, with an emphasis of membrane proteins. Details and Registration Information Tutorials from the 2011 workshop
After learning about using Rosetta to model membrane proteins, stick around to learn more about them at the Vanderbilt Center for Structural Biology conference entitled Biomolecular Structure, Dynamics, and Function: Membrane Proteins!
Register for the BSDF: Membrane Proteins Symposium!
The Vanderbilt Center for Structural Biology is hosting the Biomolecular Structure, Dynamics, and Function: Membrane Proteins Symposium from May 2-4, 2014. The Early Registration deadline is March 1, 2014! Details and Registration Information
BCL 3.1 released
The BioChemical Library (BCL) version 3.1 is now released for Linux, Windows, and Apple and is available for download on meilerlab.org. This release features a new single user academic license, which is now distributed via a webserver
on the meilerlab.org website. The new licensing systems enables users at academic and other non-profit institutions to receive a license file within seconds, along with an email detailing how to use it and install the BCL. This release also includes a number of bug fixes and enhancements, as well as a new application (protein:FusionProtein) for working with chimeric proteins. Brief summaries of all released BCL applications are available on the bclcommons webpage
. Friends and collaborators outside the lab can download the newest release from meilerlab.org and use it with a license file obtained from http://www.meilerlab.org/servers/bcl-academic-license
Daniel Putnam passes his qualifying exam
Congratulations to Daniel!
Collaborative Meiler Lab article is a winner of an intramural Highly-Cited Article Award
“Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.” is a winner of the 2014 Vanderbilt Institute for Chemical Biology's Highly-Cited Article Award. The VICB award recognizes high-impact research by Vanderbilt researchers. This publication is one of only 6 in the department with a sufficiently high impact (45 citations in total) for the 2014 awards.
Yan Xia and Jessica Finn passed their qualification exams
Congrats Yan and Jessica!
VU researchers report G protein advancement that could lead to more effective drugs
Dr. Edward W. Lowe, Jr. awarded state-of-the-art GPUs from NVIDIA
Dr. Edward W. Lowe, Jr. received a second high performance GPU hardware award from NVIDIA for his work in accelerating algorithms important in biology and chemistry using multiple GPUs. Congrats Will!
Steven McIntyre receives Littlejohn fellowship
Steven McIntyre, an undergraduate student advised by Axel Fischer in the Meiler laboratory, was selected as one of the first recipients of the Littlejohn fellowship. The fellowship encourages undergraduates to participate in research and scholarship across the humanities, natural sciences, and social sciences. Congats Steven!
MeilerLab receives NSF grant to study GPCRs with structure activity relations
Drs. Annette Beck-Sickinger and Torsten Schoeneberg from Leipzig University and Jens Meiler from Vanderbilt University receive a grant "Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions" that is jointly funded by the National Science Foundation (NSF) and the Deutsche Forschungsgemeinschaft (DFG). The grant will develop a novel docking algorithm that leverages Structure-Activity-Relations (SAR) and apply this algorithm to understand regulation of G-Protein Coupled Receptors (GPCRs).
Meet Dr. Combs
Steven Combs successfully defended his dissertation entitled "Identification and Scoring of Partial Covalent Interactions in Proteins and Protein Ligand Complexes." Congrats Steven!
MeilerLab to study Y-Receptor Ligands
The Meiler and Weaver laboratories at Vanderbilt University received a grantfrom the National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK, NIH) for the development of "Small Molecule Probes to Investigate Structure and Function of Y Receptors". This project is a collaboration Annette Beck-Sickinger at Leipzig University, Germany who is an expert on Y-receptorbiochemistry. The project is the first federally funded research grant that developed under a collaboration of Vanderbilt and Leipzig Universities in chemical biology.
Vanderbilt-Leipzig collaborations strengthened with grant from Max Kade Foundation
Vanderbilt University receives a grant from the Max Kade Foundation in support of undergraduate and graduate student exchange in a collaboration with Leipzig University spear-headed by Drs. Jens Meiler (Vanderbilt University) and Annette Beck-Sickinger (Leipzig University).
Vanderbilt - Leipzig University Symposium and Workshop
From July 6th to July 12th 2013 researchers from Vanderbilt and Leipzig Universitymeet in Leipzig for the 4th partnership symposium and scientific workshop. Drs. Gurevich, Lybrand, Mchaourab, and Meiler from Vanderbilt University participate in scientific presentations and meet faculty from Leipzig University. The Memorandum of Understanding between the two institutions will be renewed and faculty discuss the strategic objectives of the collaboration. Further, Dr. Lybrand presents a workshop in "Molecular Modeling" and Dr. Mchaourab presents a workshop in "Biomolecular EPR Spectroscopy" for graduate students
BCL 3.0 Released
The BioChemical Library version 3.0 is available for download on meilerlab.org. This release features our suite of cheminformatics and QSAR applications, along with new and improved extensions to bioinformatics applications, including JUFO9D, membrane-folding protocols, and SAXS simulation. User-interface improvements include a friendlier command line interface that offers suggestions whenever options are mistyped, and earier to read help dialogues (and many more of them!), Download the newest release from the bcl downloads page.
Darwin Fu selected for appointment to the Molecular Biophysics Training Grant
Stephanie Deluca receives NFB scholarship
Stephanie is one of only 30 recipients of this year's National Federation of the Blind Fellowship, for which there were over 700 applicants. Congratulations Stephanie!
Congratulations Tyler Gilcrest!
Tyler Gilcrest, a VU undergraduate researcher in the Meiler Lab, graduated with honors from the Vanderbilt chemistry program. Tyler's performance earned him the Thomas W. Martin award for excelling in physical chemistry. Excellent job Tyler!
Elizabeth Nguyen (co-) wins Vanderbilt's 3-minute thesis competition
The 3 Minute Thesis competition sponsored by the Vanderbilt Graduate Student Council challenged graduate students in all fields across campus to present their thesis in only 3 minutes to a diverse audience. Students were challenged to present their research topic, explain how the research is conducted, and identify what impact it will have on the general or academic community. Elizabeth Nguyen, a graduate student in the Meiler Lab, received a co-first place prize for her presentation on "Progress Towards Unlocking the Treatment for Cognitive Impairment". Her research involves the computational modeling of G-protein coupled receptors, specifically metabatropic glutamate receptor 5 and its binding site for drugs used to treat schizophrenia and Fragile X Syndrome.
Amanda Duran receives 3-year stipend from the NSF
Amanda's stipend will allow her to explore computational design of membrane protein ligand interactions. Congratulations to Amanda!
Stephanie Deluca to give talk in 2013 Biophysics conference
Stephanie will be giving a talk on RosettaEPR at the 2013 Biophysics conference in South Korea, May 22, at 10:15-10:30 AM
Meiler Lab receives grant to collaborate with researchers at Oak Ridge National Labs (ORNL)
The Meiler lab receives an ORAU/ORNL High Performance Computing (HPC) Grant: "Investigation of the Mechanism of Cellulose Synthesis in Plants Using Neutron Scattering and High Performance Computing"
Gordon Lemmon receives Biosecurity Fellowship
Dr. Lemmon received a fellowship from Emerging Leaders in Biosecurity Initiative to facilitate meeting with leaders in Biosecurity.
Sign up now for the 2012 Rosetta Workshop
Whether you are a Rosetta newcomer or an advanced user, you are invited to take part in our 2012 Rosetta workshop, Nov 13-16, to learn how Rosetta can be used for protein structure prediction. Details and Registration Information Tutorials from the 2011 workshop
Meiler Lab publication recommended by Faculty of 1000
Faculty of 1000, a large group of researchers in the fields of biology and medicine that identify the most relevant research in the field, has recommend EM-fold: de novo atomic-detail protein structure determination from medium-resolution density maps., Structure, 2012
Brian Weiner was promoted to Research Assistant Professor in Chemistry
BCL CASP team awarded CASP10 attendance fellowship
The BCL CASP team (Sten Heinze, Daniel Putnam, and Pedro Teixeira) have been awarded an attendance fellowship to defray the costs of attending the CASP conference. Congrats to the BCL CASP team!
Dr. Edward W. Lowe awarded state-of-the-art GPU from NVIDIA
Dr. Edward W. Lowe, Jr. received a high performance GPU hardware donation from NVIDIA for his work in accelerating algorithms important in biology and chemistry. Congrats Will!
VICB research symposium successes
The annual Vanderbilt Institute for Chemical Biology proved especially rewarding this year, with two winners from Meiler Lab. Daniel Putnam won an Ipad through a raffle. Mariusz Butkiewicz co-authored a poster together with Rebecca Sandlin from the David Wright laboratory "Finding the Pathway: New Machine Learning Paradigms for the Identification of Lead Compound Targets from Phenotypic Antimalarial Assays" that won a poster prize. Congratulations!
Daniel Putnam accepted into the HHMI/VUMC Certificate Program in Molecular Medicine
Meiler Lab to investigate theraputic strategies using computational design of protein-ligand interfaces
The Meiler lab was awarded an R01 grant to study "Computational Design of Protein-Ligand Interfaces - a Therapeutic Strategy" from the NIH National Institute of General Medical Sciences (NIGMS). The grant will create advanced methodology to computationally design and experimentally verify protein-ligand interfaces. It will further explore use of these methods to create protein therapeutics for treatment of prostate cancer, bacterial infection, and cocaine overdosing.
Gordon Lemmon, Steven Combs, Jordan Willis, and Sam DeLuca presented research talks at the Rosetta conference. The topics include: "Refactoring Rosetta for Chemistry", " Knowledge-Based Potentials for Partial Covalent Interactions", "Anti-HIV antibody design using Rosetta", and "RosettaQSAR - protein-ligand docking guided by pharmacophore maps"
Vanderbilt Leipzig collaboration to study Ligand -Macromolecule Recognition
The Meiler laboratory was awarded a grant "Ligand-Macromolecule Recognition: A Collaboration in Research and Education Between Vanderbilt and Leipzig University" from the NSF Office of International Science and Engineering (OISE). It is the objective of this proposal to develop a sustainable collaboration in education and research between Vanderbilt and Leipzig Universities in the area of chemical biology.
Meiler Lab alumnus Dr. Steffen Lindert is awarded postdoc fellowship
Congrats to Steffen, who received a postdoctoral fellowship from the American Heart Association
Dr. Edward W. Lowe Jr., and Dr. Nils Woetzel give talks @ the 2012 GPU Technology Conference
The topics were Bcl::ChemInfo Suite Enables Machine Learning-Based Drug Discovery Using GPUs
, and GPGPU Accelerated Protein Similarity Measures Identifying Biologically Relevant Structure
. The conference was held in San Jose, CA.
Congratulations Dr. Alexander!
Dr. Nathan Alexander successfully defended his dissertation: Protein structure elucidation from computational techniques and sparse EPR data
Daniel Putnam defends research proposal!
Daniel's research will be on the topic of Small Angle X-ray Scattering (SAXS) Restraints to Promote de Novo Protein Structure Prediction
Congratulations Dr. Koehler!
Dr. Julia Koehler successfully defended her dissertation: Method development for membrane protein structure determination using NMR spectroscopy and computational techniques
Stephanie Hirst and Sam DeLuca receive travel awards!
The awards provide financial support for presenting their research at the Computational Biophysics to Systems Biology (CBSB12) symposium.
Please join us in welcoming the Meiler Lab's newest graduate students: Amanda Duran and Yan Xia
Stephanie Hirst receives prestigious NRSA fellowship!
Stephanie Hirst receives the prestigious Ruth L. Kirschstein National Research Service Award (NRSA) from NIH for her project "Investigating the Role of Substrate Binding in LeuT Transport With RosettaEPR." Congrats Stephanie!
Meiler Lab receives an REU grant from the NSF
The Meiler laboratory receives a Research Experiences for Undergraduates (REU) grant from NSF for research related to the CAREER award: "Cryo-EM guided de novo Protein Fold Elucidation"
Meiler Lab receives grant to investigate Y4 Receptor!
The Meiler laboratory receives a pilot project grant from the Vanderbilt Diabetes Research and Training Center (DRTC) "Exploring Allosteric Modulators of Neuropeptide Y4 Receptor"
Congrats to Brittany Allsion for passing qualifying exams!
Brittany presented her research plan entitled "Computational Design of Protein-Ligand Interfaces in (beta/alpha)8 Barrels for Applications in Protein Therapeutics"
Jordan Willis invited to give a talk
Jordan Willis was invited to give an oral presentation at the Keystone Symposia on HIV Vaccines
Sam Deluca wins fellowship from Phrma foundation!
Sam DeLuca, graduate student in the Meiler laboratory, wins an "Informatics" graduate student fellowship from the Phrma foundation. Sam's research focuses on computational modeling of protein-small molecule interactions for drug discovery.
Brittany Allison receives NSF fellowship!
Brittany Allison, a chemistry student in the Meiler laboratory, received a prestigious National Science Foundation (NSF) Graduate Research Fellowship. Brittany works on computationally engineering proteins that bind small molecules. Her research has implications for understanding the fundamentals of protein-ligand interaction, engineering enzymes, and protein therapeutics. Brittany will start her fellowship after completing her training on the Chemical Biology Training Program, an NIH-funded initiative of Vanderbilt's Institute for Chemical Biology and the Chemistry Department.
Congrats to Sandeep Kothiwale for passing prequalifying exams
Sandeep presented his research plan entitled "Enhancement of drug discovery tools through knowledge based conformational sampling and chemical shift predictions"
Congrats to Daniel Putnam: 2nd place Finalist in AMIA Student Paper Competition!
Daniel Putnam's AMIA paper - "Exploring Schizophrenia Drug-Gene Interactions Through Molecular Network and Pathway Modeling", has been accepted as one of the eight finalists in the Student Paper Competition at the American Medical Informatics Association conference in October. Update 10/28/2011: Daniel was awarded 2nd place at the conference, congratulations, Daniel!
Congratulations Dr. Woetzel!
Nils Woetzel successfully defended his thesis, “A novel approach to de novo protein structure prediction using knowledge based energy functions and experimental restraints."
Zollie White receives Top Prize at the 2011 Herty Medalist Undergraduate Research Symposium
Zollie White, an undergrad from Morehouse College, spent the summer of 2011 researching with Will Lowe in the Meiler Lab through the Vanderbilt REU program. He presented this research at the 2011 Herty Medalist Undergraduate Research Symposium held at Morehouse College was awarded the top prize. For this, he received a one-year membership to the American Chemical Society (ACS) and a $500 travel award to a national ACS conference. Congrats, Zollie!
Congratulations Dr. Karakas!
Congrations to Mert Karakas for having successfully defended his thesis "BCL::Fold-De novo Protein Structure Prediction by Assembly of Secondary Structure Elements"
Will Lowe Receives NSF Fellowship
Will Lowe received an NSF fellowship for his project "PROPMAP: A Novel GPU-accelerated Structure-Property Relationship Mapping Algorithm Utilizing Volunteer Computing." The prestigious award supports Dr. Lowe's research for three years in the Meiler Lab. Congrats, Will!
Liz Dong Receives DAAD Award
Liz Dong of the Jens Meiler lab at Vanderbilt recently received a short term research grant to study at the Univeristy of Leipzig in Leipzig, Germany. She will spend one month this fall developing a computational method that will allow for the binding pose of a drug within a receptor to be determined. Her method will be guided by experimental data collected on drugs that bind G-protein coupled receptors, working with the lab of Torsten Schöneberg. Congrats, Liz!
Mariusz passes his qualifying exam!
Mariusz passed his qualifying exam with his proposal: Comprehensive protein-ligand interaction mapping through quantitative structure activity relationships. Congratulations Mariusz!
Joe Crivelli's cancer research project in the Meiler lab covered in Vanderbilt's Arts and Sciences magazine!
Meiler lab undergraduate Zachary Glaser received early acceptance into VU Medical School
Kelli Kazmier awarded a doctoral fellowship
Kelli's was awarded an NIH NRSA doctoral fellowship to investigate "Conformational Changes Underlying Intracellular Gating of the Leucine Transporter." Congratulations Kelli!
Sten passes his qualifying exam!
Sten passed his qualifying exam with his proposal: A novel approach to de novo protein structure prediction using multiple partial templates. Congratulations Sten!
Ralf Mueller earns his PhD!
Ralf successfully defended his thesis, Machine Learning Algorithms for Prediction of Biological Activity and Chemical Properties, earning his PhD, Congratulations Ralf!
Congratulations to Dr. Jens Meiler
Dr. Jens Meiler was promoted to Associate Professor with tenure.
Andrew Morin's Successful Ph.D. Defense
Congratulations to Andrew Morin on successfully defending his PhD thesis on April 26, 2011. The thesis was presented on "The Computaional Design of Protein Ligand Interfaces".
Congratulations to Steven Combs !!!
Steven Combs has successfully passed his qualifying exam on April 23, 2011 and proposed his research on "Thermostabilization of industrially relevant proteins through computational design of partial covalent interactions
Grant awarded from Vanderbilt University Discovery Grant.
Meiler Laboratory has been awarded Vanderbilt University Discovery Grant for research on "De novo Design of Large protein
Best Oral Presentation at CPB retreat from Meiler Lab
Liz Dong has won best oral presentation prize at Chemical & Physical Biology retreat at Nashville Zoo on April 18, 2011. She gave her oral presentation on "Structural studies of the interaction between mDlu5 and allosteric modulator". Congratulations to Liz !!!
Julia Koehler Won Travel Grant!!
Julia Koehler won a travel grant to attend the Gordon Research Conference "Computational Aspects - Biomolecular NMR" in May 2011 and will present her work on " De novo membrane protein folding from sparse NMR data
Brittany's Preliminary Qualification Exam
Brittany Allison, a graduate student at Meiler Lab has successfully passed her Priliminary Qualification Exam on April 6, 2011.
Summer Student from Meiler Lab Won Goldwater Fellowship
Louesa Akin is a undergraduate student attending Centre College in Kentucky who pursues research in the Meiler laboratory focused on Membrane Protein Structure Prediction using sparse NMR restraints
. She was selected to receive the Goldwater Scholarship for undergraduate students. Louesa participated in the Summer Science Academy program in summer 2010 and will participate in the Research Experience for Undergraduates in chemical biology in summer 2011.
Congratulations to Elizabeth Dong!!!
Liz Dong is a MD/PhD student in the second year of her graduate studies. She won the prestigious PhRMA
-Paul Calabresi Medical Student Research Fellowship. The fellowship is offered to medical students who have substantial interests in research and teaching careers in pharmacology - clinical pharmacology. Liz works on new technologies in the Meiler laboratory to develop allosteric modulators of metabotropic glutamate receptors, important targets for many neurological diseases.
David Nannemann - Dissertation Defense on March 25th 2011
David Nannemann will be defending his Doctoral research on "Directed Biosynthesis of the Nucleoside Analog Drug Didanosine", at the Stevenson Center, Room 5502, 2:00 pm.
Stephanie Hirst successfully passed her Qualifying Exam
Stephanie Hirst unconditionally passed her Qualifying Exam on February 3, 2011 and the proposal was called "Structural Elucidation of the Role of Na+ and Leucine Binding in the LeuT Transport Mechanism using ROSETTAEPR". Congratulations to Stephanie!!!
Steffen Lindert successfully defends his research dissertation
Steffen presented his doctoral research dissertation “CryoEM guided de-novo protein folding” on November 22nd, 2010. His thesis committee approved his presentation and accepted his research, making him the first to complete the Chemical and Physical Biology PhD Program
. Congratulations, Steffen!!
Meiler Lab member Steffen Lindert receives NIH travel award to give a presentation in Hawaii.
Steffen Lindert will give a presentation at the Pacific Symposium on Biocomputing in January on Hawaii (about EM-Fold and our results participating in the cryoEM modeling challenge). He received an NIH travel award to cover the costs associated with the conference.
Liz Dong successfully passed her Qualifying Exam in September
Congratulations to Liz Dong, an MD/PhD student in the Meiler lab, on her successful completion of qualifying exams on 9/2/2010
Meiler Lab Publication Makes the List of Top 20 Most Downloaded Biochemistry Articles!
Congratulations to Meiler Lab members Kristian W. Kaufmann, Gordon H. Lemmon, Samuel L. DeLuca, and CSB outreach coordinator, Jonathan H. Sheehan! Their recent publication, "Practically Useful: What the Rosetta Protein Modeling Suite Can Do for You" made the list of the TOP 20 most downloaded articles from the journal Biochemistry