Rosetta Design
Advances in experimental protein structure determination methods (X-ray crystallography, NMR and EPR spectroscopy, and cryo-electron microscopy (cryo-EM)) have begun to allow for predictions of protein stability and function. ...
Protein Design with NCAAs
Abnormal protein-protein interactions (PPIs) are the cause of many diseases. While traditional small molecule drugs are not feasible when targeting the broad and shallow PPIs interface, large scaffolds of biologic drugs, ...
Multi-State Design
The Meiler lab developed a multi-state design protocol which enables Rosetta protein design on multiple protein conformations simultaneously. Each protein conformation ideally represents one typical ...