About The Meiler Lab

The Meiler Lab is uniquely located both in the United States and Germany, and is actively involved in developing the Rosetta computational modeling software suite together with 15 other laboratories in the United States. As an integral part of the Rosetta community, the Meiler lab works to better understand macromolecular interactions, design custom molecules, and develop efficient ways to search conformational and sequence space.


To enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses.


Design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways.


Understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs.


Antibodies, Vaccines and Immunity

"Meiler Lab is expert in the field of structure-based reverse vaccinology. Starting from co-crystal structures of antigens and antibodies…"More DetailsCreative Solutions

Small Molecules

“Small molecules” is a vague term for all organic molecules with a molecular mass smaller than 600-800 Da. The term “small molecule…"More DetailsFinanancial Strategy

Membrane Proteins

"Membrane proteins play important roles in many biological pathways. Understanding membrane proteins may require an…"More DetailsKeyword Research

Protein Discovery and Design

"Rational protein design generates new protein macromolecules with novel functions, increased therapeutic efficacy, and novel fold patterns…"More DetailsMarketing Strategy

Personalized Structural Biology

"Personalized Structural Biology Medicine has experienced a revolution in the methods used to diagnose and treat disease. Dramatic…"More DetailsWeb Development

Diseases we cure

"Viral Infections, Cancer, Neurodegenerative diseases, and many others diseases are worked on in the Meiler Lab…"More DetailsRestructuring

Recent News

Congrats to Eli McDonald- 2024 Karpay Award Winner!

Congratulations to Eli on winning the 2024 Karpay Award in Structural Biology! He has worked in the Jens Meiler...

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Meiler Lab Undergraduate Researcher, Karen Pu, Featured in Vanderbilt...

Karen Pu, class of 2024 at Vanderbilt, was featured for her excellent research in the Meiler lab through the...

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Meiler Lab hosts first international developer retreat

The Meiler lab hosted a four-day developer retreat in the Great Smoky Mountains from July 24-27th. The focus of...

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Congrats Hope Woods on successful defense!

Meiler lab graduate student, Hope Woods, successfully defended her thesis “Development of Frameworks for Computational Protein Structure Prediction Applications...

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Ben Brown receives NIH pioneer award

Congratulations to Ben Brown, research assistant professor in the Meiler lab, on his recent NIH DP1 award for his...

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