About The Meiler Lab

The Meiler Lab is uniquely located both in the United States and Germany, and is actively involved in developing the Rosetta computational modeling software suite together with 15 other laboratories in the United States. As an integral part of the Rosetta community, the Meiler lab works to better understand macromolecular interactions, design custom molecules, and develop efficient ways to search conformational and sequence space.

1

To enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses.

2

Design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways.

3

Understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs.

Research

Antibodies, Vaccines and Immunity

"Meiler Lab is expert in the field of structure-based reverse vaccinology. Starting from co-crystal structures of antigens and antibodies…"More DetailsCreative Solutions

Small Molecules

“Small molecules” is a vague term for all organic molecules with a molecular mass smaller than 600-800 Da. The term “small molecule…"More DetailsFinanancial Strategy

Membrane Proteins

"Membrane proteins play important roles in many biological pathways. Understanding membrane proteins may require an…"More DetailsKeyword Research

Protein Discovery and Design

"Rational protein design generates new protein macromolecules with novel functions, increased therapeutic efficacy, and novel fold patterns…"More DetailsMarketing Strategy

Personalized Structural Biology

"Personalized Structural Biology Medicine has experienced a revolution in the methods used to diagnose and treat disease. Dramatic…"More DetailsWeb Development

Diseases we cure

"Viral Infections, Cancer, Neurodegenerative diseases, and many others diseases are worked on in the Meiler Lab…"More DetailsRestructuring

Recent News

Congrats Ben Brown on Rosetta Mini Grant!

Meiler lab research assistant professor Ben Brown was awarded the 2022 Rosetta mini grant for his work on BCL-Rosetta...

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Congrats to Eli McDonald on F31 Fellowship and VICB...

Congratulations to Eli McDonald on receiving an F31 fellowship for his research “Molecular Chaperone Recognition of CFTR Stability” from...

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Rocco Moretti wins 2022 Rosetta Service Award

Congratulations to Rocco Moretti for winning a 2022 Rosetta Service Award! He was recognized at the 2022 RosettaCon for...

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Christina Mercado awarded a post-baccalaureate award from RosettaCommons!

Congratulations to Christina Mercado, Meiler lab research assistant, for receiving a postbac award from the RosettaCommons. More about the...

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Jens Meiler Elected 2021 AAAS Fellow

Seven Vanderbilt University and Vanderbilt University Medical Center faculty members have been elected 2021 fellows of the American Association for...

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