My research addresses the difficulties of modelling and designing long partially structured loops in proteins computationally. My goal is to gain a deeper insight into the structural characteristics of long protein loops and to implement my results into the Rosetta framework to improve loop structure prediction. This research is imbedded in the Collaborative Research Centre 1423 “Structural Dynamics of GPCR Activation and Signal Transduction” with the aim to construct and refine GPCR comparative models.