About The Meiler Lab

The Meiler Lab is uniquely located both in the United States and Germany, and is actively involved in developing the Rosetta computational modeling software suite together with 15 other laboratories in the United States. As an integral part of the Rosetta community, the Meiler lab works to better understand macromolecular interactions, design custom molecules, and develop efficient ways to search conformational and sequence space.

1

To enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses.

2

Design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways.

3

Understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs.

Research

Antibodies, Vaccines and Immunity

"Meiler Lab is expert in the field of structure-based reverse vaccinology. Starting from co-crystal structures of antigens and antibodies…"More DetailsCreative Solutions

Small Molecules

“Small molecules” is a vague term for all organic molecules with a molecular mass smaller than 600-800 Da. The term “small molecule…"More DetailsFinanancial Strategy

Membrane Proteins

"Membrane proteins play important roles in many biological pathways. Understanding membrane proteins may require an…"More DetailsKeyword Research

Protein Discovery and Design

"Rational protein design generates new protein macromolecules with novel functions, increased therapeutic efficacy, and novel fold patterns…"More DetailsMarketing Strategy

Personalized Structural Biology

"Personalized Structural Biology Medicine has experienced a revolution in the methods used to diagnose and treat disease. Dramatic…"More DetailsWeb Development

Diseases We Cure

"Viral Infections, Cancer, Neurodegenerative diseases, and many others diseases are worked on in the Meiler Lab…"More DetailsRestructuring

Recent News

Success for the first spin-off of the MeilerLab: AI-Driven...

Last year, four PhD students from the MeilerLab at Leipzig University’s Institute for Drug Discovery launched the lab’s first...

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Congratulation Zain Tariq on a successful honors defense!

Zain Tariq has been a Meiler lab undergraduate researcher under Dr. Kaitlyn Ledwitch’s mentorship since Spring 2023. Their work...

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Congrats to Raphael Park for 2025 VUSRP Award

Undergraduate student in the Meiler lab, Raphael Park, was selected for a highly competitive VUSRP Summer immersion award. His...

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Jens Meiler interviewed for work with Nobel Laureate David...

Jens Meiler started his career as a post-doc in the laboratory of Dr. David Baker at the University of...

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Meiler Lab Team Awarded Up to $46M to Advance...

Meiler Lab Team Awarded Up to $46M to Advance Vaccine Research Against Alphaviruses Major funding from ARPA-H will support...

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