Rosetta Antibody Workshop 2019

A workshop focusing on antibodies was held in April of 2019. Based on Rosetta weekly release 2019.07, this workshop included hands-on tutorials for RosettaAntibody structure prediction, antibody-antigen docking, computational affinity maturation, antibody structure redesign, glycan modeling, and epitope grafting onto scaffolds, as well as presentations on Rosetta basics.

Main Topics:

Tutorial 1: RosettaAntibody Structure Prediction

• Presentation (pdf)
• Tutorial (pdf)
• Tutorial Materials (zip)

Tutorial 2: Antibody-Antigen Docking

• Presentation (pdf)
• Tutorial (pdf)
• Tutorial Materials (zip)

Tutorial 3: Computational Affinity Maturation

• Presentation (pdf)
• Tutorial (pdf)
• Tutorial Materials (zip)

Tutorial 4: RosettaAntibodyDesign (with Jared Adolf-Bryfogle)

• Presentation (pdf)
• Tutorial (pdf)
• Tutorial Materials (zip)

Tutorial 5: Glycan Modeling (with Jared Adolf-Bryfogle)

• Presentation (pdf)
• Tutorial (pdf)
• Tutorial Materials (zip)

Tutorial 6: Epitope Grafting

• Presentation (pdf)
• Tutorial (pdf)
• Tutorial Materials (zip)

Short Talk Topics:

Short Talk 1: Introduction to Antibodies

• Presentation (pdf)

Short Talk 2: Navigating Rosetta and I/O

• Presentation (pdf)

Short Talk 3: RosettaScripts XML

• Presentation (pdf)

Short Talk 4: Rosetta Energy Function

• Presentation (pdf)