On February 17 (last week), Vanderbilt's ACCRE cluster was to have been upgraded with 3PB of new storage. This critical upgrade is not in production, although we expect resolution within a very few days. Our web server will be returned to service at that point.
Although storage is temporarily constrained, limited runs of VUStruct remain available at Vanderbilt - outside the web input form.
Please Contact Us if you would like to open a collaboration.
We shall update this page at least weekly.Disease emergence through compound heterozygous variation is well understood. Individually, a Proband’s disease-free parents’ gene functions enough under single variation. But the combination of gene variants from each parent triggers creates the observed phenotype in the proband. Thus, compound heterozygous variant pairs are always given special attention in each week’s UDN review.
Multigenic disease can analogously arise when two genes in a single pathway are damaged via variations inherited from each parent.
An increasing database of annotated digenic(Gazzo et al. 2016) and multigenic(Nachtegael et al. 2022) diseases is being curated from the literature. Former Ph.D. student Souhrid Mukherjee asked whether latent digenic diseases might be predicted through machine learning strategies, and he produced a tool called DiGePred(Mukherjee et al. 2021) Another group broadened the training inputs, while retaining a similar machine architecture, to create DIEP(Yuan et al. 2022)
Add sample figure here.