The VUStruct Pipeline is moving to Leipzig University. Unfortunately, web input of variants will not be possible during this transition.
The VUStruct backend will continue to run and we'd still welcome the opportunity to process variants for you. Please reach out to discuss your project.
Thanks for all the collaborators who made this possible. Please now cite: VUStruct: A compute pipeline for high throughput and personalized structural biology
If you have any difficulties using VUStruct, please Get in touch.Post-translational modifications to proteins are often critical to function. However, these modifications (phosphorylation, glycosylation, and others) are typically unresolved in experimental X-ray structures, and never seen in model structures. Sequence-based prediction of post-translational modification sites has been evolving in recent decades, and we have integrated MutsiteDeep (Wang et al. 2017), the first deep-learning framework for prediction of these sites.
We report variants at sites predicted to have at least a 50% likelihood of post-translational modification.