The ACCRE support team introduced a security patch that caused an OS function to fail, and an obscure python error in the pipeline.
Workarounds have been installed in VUStruct. Please resubmit your variants. Thanks for your patience and understanding.
Thanks for all the collaborators who made this possible. Please now cite: VUStruct: A compute pipeline for high throughput and personalized structural biology
If you have any difficulties using VUStruct, please Get in touch.Post-translational modifications to proteins are often critical to function. However, these modifications (phosphorylation, glycosylation, and others) are typically unresolved in experimental X-ray structures, and never seen in model structures. Sequence-based prediction of post-translational modification sites has been evolving in recent decades, and we have integrated MutsiteDeep (Wang et al. 2017), the first deep-learning framework for prediction of these sites.
We report variants at sites predicted to have at least a 50% likelihood of post-translational modification.