2026 June 10: VUStruct is down.

A database server went offline nad we are tracking this down with all energy

2026 May 07: VUStruct has been published!

Thanks for all the collaborators who made this possible. Please now cite: VUStruct: A compute pipeline for high throughput and personalized structural biology

If you have any difficulties using VUStruct, please Get in touch.


Post-translational Modifications (PTMs)

Post-translational modifications to proteins are often critical to function. However, these modifications (phosphorylation, glycosylation, and others) are typically unresolved in experimental X-ray structures, and never seen in model structures. Sequence-based prediction of post-translational modification sites has been evolving in recent decades, and we have integrated MutsiteDeep (Wang et al. 2017), the first deep-learning framework for prediction of these sites.

We report variants at sites predicted to have at least a 50% likelihood of post-translational modification.