The new 3PB strorage module on Vanderbilt's compute cluster has exhibited extremely slow response. This is being addressed by IT teams - and we expect improvements within the week. Our web server will be returned to service at that point.
Although storage performance is problematic, limited runs of VUStruct remain available at Vanderbilt - outside the web input form.
Please Contact Us if you would like to open a collaboration.
Mutations in protein coding regions can be deleterious through various mechanisms(Taipale 2019). To holistically inform structural biologists, VUStruct accepts sets of Variants of Unknown Significance (VUSs) as either a VCF file of human genomic coordinates or as a CSV list of amino acid changes to specific Uniprot proteins. The pipeline automatically selects protein structures which cover missense variants, launches the compute jobs on Vanderbilt's ACCRE computer cluster, and creates a final drill-downable report page
These documentation pages provide pipeline input examples, output report examples, and documents our thinking on how the suite of computational methods, together with the generated website, inform hypothesis generation.
The VUStruct compute pipeline is intended only for academic research, and is provided free of charge to all users, including commercial users.